Protein Details: Potassium voltage-gated channel subfamily S member 2

Protein ID

ICDB_Pro_0206

Protein Name

Potassium voltage-gated channel subfamily S member 2

Gene Name

Kcns2

Organism

Mus musculus (Mouse)

Length

477 amino acids

AlphaFoldDB

AF-O35174-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2

Sequence

MTRQSLWDVSDTDVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLDDSLH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in brain; but not in the other tissues tested. Expression was highest in the olfactory bulb; cerebral cortex; hippocampus; habenula; basolateral amygdaloid nuclei and cerebellum (PubMed:9305895).

DOI ID

10.1074/jbc.272.39.24371; 10.1126/science.1112014; 10.1101/gr.2596504

RefSeq

NP_001258633.1; NP_851834.1